This Practice Note provides practical guidance to those involved in global investigations, whether they be global internal investigations or regulator-led investigations involving multiple overseas enforcement agencies. It covers identifying who is investigating eg investigations into violations of the US Foreign Corrupt Practices Act 1977 (FCPA 1977) which may involve the Department of Justice (DOJ) and Securities and Exchange Commission (SEC) among others, and where they are being investigated alongside eg bribery and corruption allegations in the UK involving UK investigating agencies such as the Serious Fraud Office (SFO), Financial Conduct Authority (FCA), Financial Reporting Council (FRC) or Competition and Markets Authority (CMA). It covers how the investigation has been initiated (whether by a whistleblower or external agency) and issues that arise in the context of internal investigations (such as privilege and who the client is). It considers the way regulator interviews can be conducted (voluntarily, under caution etc) as well as what it means to self-report and co-operate in the UK and US for the purposes of securing a negotiated settlement such as a deferred prosecution agreement (DPA) or a declination.