This Practice Note covers the labelling requirements for chemical substances and mixtures under Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures, as amended in 2024 pursuant to Regulation (EU) 2024/2865 (the EU CLP Regulation). It details the key labelling obligations, available derogations and exemptions, who is responsible for labelling, general labelling requirements, an explanation of mandatory labelling elements (including product identifiers, hazard pictograms, signal words, hazard statements, precautionary statements, and supplemental information), and provisions introduced in 2024 on voluntary digital labelling and labelling rules applicable to online distance sales and refill stations.